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Hence, in the spleens CD4 + FoxP3 + Tregs were increased, while proarthritic Th1 (CD4 + Tbet + ) and Th17 (CD4 + RORt + ) were decreased (Supplementary Fig

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[2] The bar for FDA drug approval is extremely high, and many compounds that fall short of that bar still have meaningful clinical utility under medical supervision

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